In vivo characterization of a tumor suppressor associated
 with high-risk myeloid neoplasms

CUX1 is a transcription factor gene frequently inactivated in myeloid cancers and certain solid tumors. Myeloid cancers with loss of CUX1 are difficult to treat and carry a poor prognosis.

The proposed research will define the phenotypes and pathways in hematopoietic cells that are altered by CUX1 inactivation and may therefore identify new therapeutic targets that ultimately improve the outcome for patients with these diseases.