North American Consortium for Familial Hematologic Malignancies
Early Detection of Undiagnosed Familial MDS/Acute Leukemia Predisposition Syndrome Families in the Matched Related Donor Hematopoietic Stem Cell Transplant Setting
This pilot program suggests the opportunites for research and improved clinincal care that the North American Consortium for Familial Hematologic Malignancies might provide.
One of the most devastating aspects of FHMs is that many of them exhibit "anticipation," which means that each successive generation is predisposed to develop cancer earlier in life. In fact, grandchildren can develop disease before their grandparents. One goal of thr project is to locate the mechanism of anticipation.
Another aspect of FHMs is that carriers exhibit unusual blood cell behavior. When a leukemia patient needs a stem cell transplant, a matched family member is considered the best donor. Occasionally, matched related donors do not react normally to stem cell stimulating drugs, indicating unusual blood behavior.The study will also seek a genetic correlation linking this behavior to an FHM. If a connection between genes linked to FHM and unusual donor blood behavior is found, then a new protocol will be suggested to perform FHM related genetic testing on donors to identify potential FHM patients, treat them preventatively and disallow them from donating their stem cells.
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