Akash Patnaik, MD, PhD, MMSc - 2016 Young Investigator Award
“Perturbing DNA repair Pathways to Enhance Immune- responsiveness in Prostate Cancer”
Awarded a $75,000 Young Investigator Award
The pharmaceutical industry has focused on developing drugs that target critical tumor-promoting pathways, including DNA repair pathways, within cancer cells. However, the impact of these drugs on the activation and/or trafficking of immune cells into the cancer microenvironment remains poorly understood. In this proposal, we aim to elucidate the effect of drugs known to inhibit the DNA repair protein PARP, on the immune microenvironment within prostate cancer. We anticipate that a deeper understanding of the immune effects mediated by PARP inhibitors will lead to the development of novel combinations that make immunotherapy more effective in advanced prostate cancer.
"I owe a great deal to the Cancer Research Foundation for giving me a head start. This financial help made the difference between my getting a fast and successful start, and my other wise struggling to obtain the necessary funds to get my research program started."Elaine Fuchs, Ph.D.
Professor, Departments of Medicine and Molecular Genetics and Cell Biology and Human Genetics University of Chicago
April 30, 2010