Akash Patnaik, MD, PhD, MMSc - 2016 Young Investigator Award
“Perturbing DNA repair Pathways to Enhance Immune- responsiveness in Prostate Cancer”
Awarded a $75,000 Young Investigator Award
The pharmaceutical industry has focused on developing drugs that target critical tumor-promoting pathways, including DNA repair pathways, within cancer cells. However, the impact of these drugs on the activation and/or trafficking of immune cells into the cancer microenvironment remains poorly understood. In this proposal, we aim to elucidate the effect of drugs known to inhibit the DNA repair protein PARP, on the immune microenvironment within prostate cancer. We anticipate that a deeper understanding of the immune effects mediated by PARP inhibitors will lead to the development of novel combinations that make immunotherapy more effective in advanced prostate cancer.
"Thanks to the hard work, commitment, and compassion of scientists, researchers, and organizations like the Cancer Research Foundation, there is renewed hope for discovering better treatments and eventually a cure for cancer.
I commend all of you for your outstanding contributions to the field of cancer research. For five decades, your commitment to the crusade against cancer has given hope and comfort to people across the nation."
Former President of the United States
May 05, 1997