Jason Luke, MD, FACP - 2015 Young Investigator Award
"Determination of Tumor-intrinsic Somatic Alterations Associated with the Presence or Absence of a T cell- inflamed Tumor Micro-environment in Human Cancer."
Awarded a $75,000 Young Investigator Award
Immunotherapy is revolutionizing cancer treatment however many patients do not benefit. Our group has proposed a model for understanding which patients will benefit from immunotherapy known as the "T cell- inflamed tumor microenvironment." Our group has also recently defined the first cancer specific molecular change (WNT/β-catenin) that leads to exclusion of immune cells from melanoma. In this research, we will analyze 30 solid tumor cancers by gene expression and exonic DNA sequencing from The Cancer Genome Atlas, looking for molecular pathways associated with immune exclusion in each tumor type. After validating our findings in human cancer specimens we will propose a rationally developed clinical trial of a targeted molecular inhibitor with immunotherapy.
The Cancer Research Foundation has focused attention on cancer and raised money for life-giving research. We...pay tribute to the scientists who have dedicated themselves to finding a cure and to meet the young researchers who are the next generation of fighters against this disease. The message we send today is that those who suffer from cancer are not alone and that together we can work toward a solution."Richard M. Daley
Mayor, City of Chicago
May 20, 1997