Jun Huang, PhD - 2015 Young Investigator Award
“Single-cell Sequencing to Define the Sequences, Phenotypes and Functionalities of Tumor Antigen Specific CD8+ T Cells from Lymphoma Patients”
Awarded a $75,000 Young Investigator Award
President Obama announced the ‘precision medicine initiative’ in January of 2015, and this proposed research will focus on ‘precision T-cell immunotherapy to cancer.’ CD8+ killer T cells are major mediators of anti-tumor immunity. However, little is known about how CD8+ killer T cells respond to cancer cells, especially their number, frequencies, specificities, sequences, phenotypes and functionalities in cancer patients. Thus, this projects aims to precisely measure these important properties at the single-cell level. Investigators will first use their newly developed high-avidity peptide-MHC dodecamer reagents to sensitively and specifically detect, quantify and isolate tumor antigen-specific CD8+ T cells from lymphoma patients. They will then further apply state-of-the-art single-cell sequencing technologies to simultaneously determine the T cell receptor sequences and functional phenotypes of these CD8+ T cells at the single-cell level. The quantitative knowledge acquired from this study is critical to the development of the next generation of precision medicine for cancer immunotherapy.
"Thanks to the hard work, commitment, and compassion of scientists, researchers, and organizations like the Cancer Research Foundation, there is renewed hope for discovering better treatments and eventually a cure for cancer.
I commend all of you for your outstanding contributions to the field of cancer research. For five decades, your commitment to the crusade against cancer has given hope and comfort to people across the nation."
Former President of the United States
May 05, 1997