Bryan Dickinson, PhD - 2014 Young Investigator Award
“Proteases reprogrammed through evolution as novel cancer therapies”
Awarded a $75,000 Young Investigator Award.
This proposal exploits the investigator and institution’s strengths and capabilities in bioengineering to develop innovative approaches to the treatment of cancer. Specifically, the proposal will examine the reprogramming of human proteases, enzymes that destroy other proteins based on their composition, to combat cancer. Investigators will develop and apply a novel evolution system that will allow them to quickly repurpose human proteases to target and degrade specific cancer-causing proteins of interest. They will then explore the utility of human protease-based cancer therapies as a novel method to control the levels of misregulated, cancer-causing proteins, for the development of completely new therapeutic strategies.
"I owe a great deal to the Cancer Research Foundation for giving me a head start. This financial help made the difference between my getting a fast and successful start, and my other wise struggling to obtain the necessary funds to get my research program started."Elaine Fuchs, Ph.D.
Professor, Departments of Medicine and Molecular Genetics and Cell Biology and Human Genetics University of Chicago
April 30, 2010