Bryan Dickinson, PhD - 2014 Young Investigator Award
“Proteases reprogrammed through evolution as novel cancer therapies”
Awarded a $75,000 Young Investigator Award.
This proposal exploits the investigator and institution’s strengths and capabilities in bioengineering to develop innovative approaches to the treatment of cancer. Specifically, the proposal will examine the reprogramming of human proteases, enzymes that destroy other proteins based on their composition, to combat cancer. Investigators will develop and apply a novel evolution system that will allow them to quickly repurpose human proteases to target and degrade specific cancer-causing proteins of interest. They will then explore the utility of human protease-based cancer therapies as a novel method to control the levels of misregulated, cancer-causing proteins, for the development of completely new therapeutic strategies.
"Thanks to the hard work, commitment, and compassion of scientists, researchers, and organizations like the Cancer Research Foundation, there is renewed hope for discovering better treatments and eventually a cure for cancer.
I commend all of you for your outstanding contributions to the field of cancer research. For five decades, your commitment to the crusade against cancer has given hope and comfort to people across the nation."
Former President of the United States
May 05, 1997