Lev Becker, PhD - 2014 Young Investigator Award
“Metabolically activated macrophages in obesity-associated breast cancer”
Awarded a $75,000 Young Investigator Award.
Emerging data suggest that obesity is strongly linked to the severity of triple negative breast cancer (TNBC); thus, obesity must be taken into account in understanding and treating patients with TNBC. This application will test a novel mechanism to explain how obesity increases the severity of breast cancer. Investigators propose that breast adipose tissue releases fat, which causes a specific immune cell type, called macrophages, to change from fighting cancer to promoting cancer. Understanding this mechanism through the studies proposed here should assist in developing better therapeutics aimed at treating obesity-associated breast cancer.
"Thanks to the hard work, commitment, and compassion of scientists, researchers, and organizations like the Cancer Research Foundation, there is renewed hope for discovering better treatments and eventually a cure for cancer.
I commend all of you for your outstanding contributions to the field of cancer research. For five decades, your commitment to the crusade against cancer has given hope and comfort to people across the nation."
Former President of the United States
May 05, 1997