Megan McNerney, MD, PhD - 2013 Young Investigator
“In Vivo Characterization of a Tumor Suppressor Associated with High-Risk Myeloid Neoplasms”
Awarded a $75,000 Cancer Research Foundation Young Investigator Award
CUX1 is a transcription factor gene frequently inactivated in myeloid cancers and certain solid tumors. Myeloid cancers with loss of CUX1 are difficult to treat and carry a poor prognosis.
The proposed research will define the phenotypes and pathways in hematopoietic cells that are altered by CUX1 inactivation and may therefore identify new therapeutic targets that ultimately improve the outcome for patients with these diseases.
"I owe a great deal to the Cancer Research Foundation for giving me a head start. This financial help made the difference between my getting a fast and successful start, and my other wise struggling to obtain the necessary funds to get my research program started."Elaine Fuchs, Ph.D.
Professor, Departments of Medicine and Molecular Genetics and Cell Biology and Human Genetics University of Chicago
April 30, 2010