Paula Jill Hurley 1999 - 2000 Bernice Goldblatt Fellow
1999 - 2000 Bernice Goldblatt Fellow
The Goldblatt Fellowship program funded the first two years of my training at the University of Chicago. Thus, I am very thankful for the generous contributions of the Goldblatt family. Having this funding early in my training provided me the opportunity to work in the laboratory of Averil Ma, MD, for my thesis work. It is this type of funding that has enabled me to pursue an academic career as a cancer biologist. Now, as a junior faculty member, I really understand the tremendous impact that these types of grants have for not only the trainee, but also the mentor, the university, and the advancement of medical discovery. On a personal note, I feel honored to have met members of the Goldblatt family, and I am inspired by their continued philanthropy to the University.
I completed my PhD studies at the University in 2004 and went on to complete a post-doctoral fellowship in radiation oncology at Johns Hopkins University. I am now an instructor of urology at Johns Hopkins University. My lab group specializes in prostate development and prostate cancer. Specifically, my lab is working to better our understanding of the biologic determinants that drive aggressive and recurrent prostate cancer. Insights into disease recurrence are critical for the development of both prognostic biomarkers to guide therapeutic decisions and targeted therapies to treat aggressive prostate cancers not cured by current therapies. We have recently demonstrated that pathways essential for prostate organogenesis are reactivated in prostate cancer making early prostate development an excellent model system for the investigation of genes and pathways potentially driving prostate cancer progression. Using this model system, we have recently identified a gene/protein that inhibits cellular migration and invasion, is lost in aggressive prostate cancer and is an independent marker for poor clinical outcome.
"I owe a great deal to the Cancer Research Foundation for giving me a head start. This financial help made the difference between my getting a fast and successful start, and my other wise struggling to obtain the necessary funds to get my research program started."Elaine Fuchs, Ph.D.
Professor, Departments of Medicine and Molecular Genetics and Cell Biology and Human Genetics University of Chicago
April 30, 2010