Qianfei “Jeffrey” Wang, Ph.D. - 2007 Young Investigator Award
Application of Genomic Approaches in Understanding MLL Fusion Protein Mediated Oncogenic Gene Activation
Fusion proteins occur frequently in several different forms of leukemia. My study aims to identify the process that occurs when these proteins promote the expression of certain types of genes that contribute to these diseases. Using a combination of biochemical and genomic approaches, I will dissect the process by which fusion proteins cause these genes to be expressed. Understanding of this gene expression in leukemia cells may facilitate the development of targeted novel therapeutic agents that could be used to help treat these forms of leukemia correcting the aberrant transcriptional process.
"I owe a great deal to the Cancer Research Foundation for giving me a head start. This financial help made the difference between my getting a fast and successful start, and my other wise struggling to obtain the necessary funds to get my research program started."Elaine Fuchs, Ph.D.
Professor, Departments of Medicine and Molecular Genetics and Cell Biology and Human Genetics University of Chicago
April 30, 2010